InvivoGen pdrive5s-hcea pDRIVE5SEAP-hCEA pDRIVE-CEA Contents update notification All InvivoGen plasmids are now provided as lyophilized DNA. Specifications: pDRIVE bearing human CEA promoter - LacZ, SEAP or Lucia Gene Promoter: Carcinoembryonic Antigen Specificity: Epithelial cancers Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia Selection: Zeocin™ Contents: - Provided as 20 µg lyophilized DNA. - 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar). Description: The carcinoembryonic antigen (CEA) is a cell surface glycoprotein that is overexpressed in colorectal and other cancers of epithelial cell origin. The CEA promoter has been used to induce tumor-selective expression of exogenous genes in human colorectal [1], gastric [2] and lung cancers. In CEA producing cells, the CEA promoter has been shown to be as efficient as the SV40 enhancer/promoter in driving expression of therapeutic genes [1]. 1. Cao G. et al. 1998. Comparison of carcinoembryonic antigen promoter regions isolated from human colorectal carcinoma and normal adjacent mucosa to induce strong tumorspecific gene expression. Int J Cancer 78:242-247. 2. Lan KH. et al. 1997. In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma. Cancer Res. 57(19):4279-84. Details:
ORDERINGpDRIVE-hCEADescription | pDRIVE bearing human CEA promoter - LacZ |
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Cat. Code | pdrive-hcea |
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Unit Size | 20 µg |
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pDRIVE5SEAP-hCEADescription | pDRIVE bearing human CEA promoter - SEAP |
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Cat. Code | pdrive5s-hcea |
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Unit Size | 20 µg |
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pDRIVE5Lucia-hCEADescription | pDRIVE bearing human CEA promoter - Lucia |
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Cat. Code | pdrive5lc-hcea |
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Unit Size | 20 µg |
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